Endocrine Abstracts

Introduction: Primary thyroid lymphoma (PTL) is responsible for 0.6–5% of all cases of thyroid cancer and less than 2% of all extranodal lymphomas. PTL is more common in elderly women and are commonly of B-cell origin. Current treatment regimens for PLC consist of chemotherapy and external beam radiation. Surgery plays an important role, including the control of symptoms in large obstructive lymphomas.Aims and methods: Retrospective data review of p...

Context: Several specific transcriptional factors, in view of their important role in thyroid organogenesis and thyroid specific gene expression, would be strong candidate genes for the etiology of TD. The homeobox transcription factor NKX2.5 was thought to be only required for the organogenesis of the heart tube. However, NKX2.5−/− embryos also exhibited a smaller outgrowing thyroid bud. Indeed, several loss ...